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Comprehensive Otolaryngology

(216) Eating Disorders Are Associated with Sialadenitis and Salivary Gland Hypertrophy Outside Traditional Models

Saturday, October 17, 2026

Presenting Author(s)

Sanjana Nallapaneni, MPH

Medical Student
Northeast Ohio Medical University
Canfield, OH, United States

Co-Author(s)

Daniel Karasik, MD

Resident Physician
University Hospital Case Medical Center/Case Western Reserve University School of Medicine
Beachwood, Ohio, United States
Alexandra F. Welschmeyer, MD

Resident Physician
Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center
Cleveland, OH, United States
Cyrus C. Rabbani, MD

Attending Physician
Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center
Cleveland, OH, United States
SG

Saikrishna C. Gourishetti, MD

Attending Physician
Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center
rocky river, OH, United States

Senior Author(s)

Raisa O. Tikhtman, MD

Attending Physician
Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States

Introduction: Eating disorders (EDs), including anorexia nervosa, bulimia nervosa (BN), and binge eating disorder, are linked with metabolic and inflammatory dysregulation. While salivary gland hypertrophy (SGH) is correlated with BN, associations with EDs generally are poorly understood. Furthermore, while non-inflammatory SGH is correlated with BN, sialadenitis risk for ED patients is not well characterized. Therefore, this study evaluates associations between (1) EDs and sialadenitis and (2) EDs and SGH.

Methods: A retrospective cohort study was conducted using TriNetX and included electronic health records from January 2023 to 2026. Cohorts including patients with any ED diagnosis (N=496,986-499,659; ICD-10-CM: F50-F50.25, F50.8-F50.89, F50.81-F50.813) were compared with matched controls with no ED diagnosis and BMI≥18 (N=497,003-499,676). Propensity-score matching occurred for age, sex, and diabetes. Outcomes included sialadenitis (ICD-10-CM: K11.2, K11.20, K11.21, K11.22, K11.23) and SGH (ICD-10-CM: K11.1). Binary logistic regression with z-tests generated odds ratios (ORs), 95% confidence intervals (CIs), and p-values. P< 0.05 was considered significant.

Results: Compared with matched controls, ED patients had elevated odds of sialadenitis (OR 5.96, 95% CI 4.81-7.40 p< 0.0001). Salivary gland hypertrophy was also increased for ED patients (OR 9.80, 95% CI 5.11-18.79, p< 0.0001).

Conclusions: EDs are associated with sialadenitis and SGH. These findings suggest that all ED patients, as opposed to uniquely BN patients, face an increased incidence of SGH and that ED patients may have elevated sialadenitis incidence. Increased clinical vigilance and timely otolaryngologic care may improve the detection and management of salivary gland conditions for all ED patients.