Icon Legend

This session is not in your schedule.

This session is in your schedule. Click again to remove it.

Presentation Icons

Audio Recorded Session

Poster Icons

Best in Basic/Clinic Science

Best in Show

Honorable Mention in Business of Medicine

Honorable Mention in Comprehensive Otolaryngology

Honorable Mention in Endocrine Surgery

Honorable Mention in Care Equity, Quality and Safety

Honorable Mention in Facial Plastic and Reconstructive Surgery

Honorable Mention in Global Perspectives in Otolaryngology

Honorable Mention in Head and Neck Surgery

Honorable Mention in Laryngology/Broncho-Esophagology

Honorable Mention in Otology/Neurotology

Honorable Mention in Pediatric Otolaryngology

Honorable Mention in Professional and Personal Development

Honorable Mention in Rhinology/Allergy

Honorable Mention in Sleep Medicine

17 Views

Comprehensive Otolaryngology

(222) Impact of Cannabis Use on Outcomes Following Surgical Repair of Maxillomandibular Trauma

Saturday, October 17, 2026

Presenting Author(s)

MT

Mishek Thapa, BS

Medical Student
David Geffen School of Medicine, University of California, Los Angeles
Los Angeles, CA, United States

Co-Author(s)

NV

Nathan Vu, BS

Medical Student
David Geffen School of Medicine, UCLA, United States
Albert Y. Li, BA

Medical Student
Keck School of Medicine
Los Angeles, CA, United States
ML

Matthew E. Lin, MD

Resident Physician
UCLA Department of Head and Neck Surgery
Los Angeles, California, United States
IK

Ian Kim, PhD

Senior Research Scientist
Department of Pediatrics, Stanford Medicine, Stanford, California, USA; Stanford Prevention Research Center, Stanford Medicine, Stanford, California, USA.
Stanford, CA, United States

Senior Author(s)

PH

Peter S. Han, MD

Assistant Clinical Professor
UCLA Department of Head and Neck Surgery
Los Angeles, California, United States

Introduction: Dental restorations represent chronic oral exposures considered safe, yet population-level data on associations with oral precancerous lesions and malignancy remain limited. Given the high prevalence of dental fillings, understanding these associations is essential for patient counseling and materials selection.

Methods: Retrospective cohort analysis using TriNetX evaluated whether dental restorations modified incident oral cavity cancer, salivary gland cancer, and leukoplakia risk. Patients receiving fillings (direct: amalgam/resin; indirect: crowns/inlays) before 2021 with ≥5-year follow-up were compared to controls receiving dental care without restorations. Cohorts were propensity-matched 1:1 for demographics, tobacco/alcohol/cannabis use, socioeconomic factors, comorbidities, and dental caries. Analyses stratified by age and restoration type.

Results: Among 97,342 matched pairs, dental fillings were associated with increased oral leukoplakia (HR 1.50[95%CI 1.12-2.00], p=0.006) and salivary gland cancer (1.93[1.02-3.67], p=0.04). Direct restorations were associated with increased leukoplakia (HR 1.46 p=0.010) and minimal oral cavity cancer increase (HR 1.48, p=0.037). Resin composites (HR 1.70, p=0.001) and amalgam (HR 1.62, p=0.070) showed elevated leukoplakia relative to controls while indirect restorations demonstrated strongest leukoplakia increases (HR 2.21, p=0.011). Age stratification revealed increased leukoplakia in patients 18-60 years (HR 1.79, p=0.015) but not ≥60 years. No associations observed for other head and neck sites.

Conclusions: Dental restorations associated with increased leukoplakia and modest salivary gland cancer. Indirect restorations showed strongest leukoplakia association; direct restorations showed leukoplakia and borderline oral cavity cancer elevations unsupported in material analyses. Absence of parallel oral cavity cancer increases suggests non-causal mechanisms including mucosal irritation or surveillance bias rather than carcinogenic effects.