(1270) The prevalence and impact of depression in adult chronic rhinosinusitis patients

Introduction: Depression symptoms are common amongst adults with chronic rhinosinusitis (CRS) however there is limited research on rates of comorbid depression diagnoses and its impact on CRS treatment.

Methods: Retrospective analysis of adult patients diagnosed with CRS presenting to an otolaryngology clinic at an academic medical center between June 2020-June 2024. All patients received medical management with a subset also undergoing endoscopic sinus surgery (ESS). Symptoms were measured with the Sino-nasal Outcome Test (SNOT-22) at baseline and at each follow-up visit occurring every 3-6 months.

Results: Sample consisted of 464 CRS patients with mean age of 50.8 (SD=16.1) and similar gender distribution (51.5% female). Within this sample, 41.8% had two or more follow-ups, 46.6% required ESS, and 18.3% had comorbid depression diagnosis. Groups with and without depression did not significantly differ in rates of follow-up or surgery. At baseline, SNOT-22 total, psychological, and sleep subscale scores were higher in patients with depression (baseline scores=46.81 vs 41.48, 14.66 vs 11.93, 13.62 vs 11.47, respectively; p< 0.05 for all). In general linear models with the patients who had two follow-up visits, those with depression had worse improvement in SNOT-22 total and psychological and sleep subscale scores over time (follow-up scores=40.13 vs 26.17, 13.03 vs 7.11, 12.72 vs 7.56, respectively; p< 0.05 for all).

Conclusions: CRS patients with comorbid depression have higher baseline SNOT-22 scores and worse improvement which are driven by the psychological and sleep symptom subdomains.